Trending on X about Biohacking

Anthropic just dropped the best blog on how to do software engg interviews in an AI world. It explains 1. How AI easily beat humans in their old interview problem 2. Why they still need SWEs when AI can do most things...

CATHIE WOOD CALLS OPTIMUS HUMAN-LEVEL BY 2028 ON 1GW COMPUTE SURGE ARK Invest's 2026 robotics deep dive just laid out a bold timeline: Tesla Optimus reaching human-level task proficiency around 2028, riding a sustained AI compute explosion to 1.08 gigawatts....

𝐈 𝐝𝐞𝐬𝐢𝐠𝐧𝐞𝐝 𝐚 𝐟𝐢𝐭𝐧𝐞𝐬𝐬 𝐚𝐩𝐩 𝐡𝐨𝐦𝐞 𝐬𝐜𝐫𝐞𝐞𝐧 𝐭𝐡𝐚𝐭 𝐚𝐧𝐬𝐰𝐞𝐫𝐬 𝐨𝐧𝐞 𝐪𝐮𝐞𝐬𝐭𝐢𝐨𝐧 𝐢𝐧𝐬𝐭𝐚𝐧𝐭𝐥𝐲: “Am I active today?” Clear stats, strong visua...

Testosterone is what keeps men alive. Testosterone improves: • Muscle building • Fat loss...

Testosterone is what keeps men alive. Testosterone improves: • Muscle building • Fat loss...

“Content ideas are not the bottleneck.” We spoke to a regenerative systems developer - permaculture/ living landscapes. Active professionals are not lacking ‘what to say.’...

Aging isn’t what slows men down. Hormonal decline is. After 30, testosterone trends down year after year unless you support it....

Aging isn’t the enemy. Neglect is. Testosterone drops year after year if you don’t support it....

Your body doesn’t stop making testosterone with age. It becomes less efficient at it. Shilajit helps improve the efficiency of hormone production by supporting cellular energy and enzyme function....

velocity is all that matters. speed. we have to go fast. faster than we think is possible. the individual is too slow. the swarm is the only organism fast enough to survive what's coming.

Swiss Entrepreneur Has Found Yet Another Use For AI – "Suicide Pods" That Determine if a Patient is Mentally Stable Enough to Die s.barstool.link/c/article-3561…

This is a great discussion by @elonmusk at the WEF in Davos on how Optimus will help the elderly. Our population is aging rapidly. Just the other day my grandmother fell and broke her hip. She lives by herself about an hour drive from me, so it's difficult to be there all the...

You’re right @elonmusk. Focus on this topic. Aging has a relatively simple explanation and is apparently reversible. Clinical trials begin shortly🤞

Prediction: the energy and compute hardware (chips, cooling, etc.) bottleneck will incentivize the evolution of models that are increasingly more energy and compute efficient. I suspect we’ll cross the barrier of (mostly) self-improving AI before we unlock major upscales of energy and compute, which means at least three things become likely: 1.) Self-improving AI will begin to increase energy-efficient and hardware-efficient intelligence rapidly, bringing massive unlocks in edge devices like AR glasses, live video AI, and robotics way faster than with only human development and way before energy and hardware start to scale exponentially. Likely in 2026-2028....

This can only be done if the inference is tracked and attributed. And only if the model usage is tracked and attributed. And only if the training data is tracked and attributed....

finally beat opus 4.5 on anthropic take home challenge, it is truly kernel optimization fun

Your body repairs itself when it can relax. Magnesium supports deeper sleep, where repair actually happens. Poor recovery accelerates aging faster than stress....

Spending 60k over five years “biohacking” only to realize taking 10x the govts recommended dose of vitamin D cures all your problems

You don’t stop producing testosterone with age. It becomes 1% less efficient every year after 30. Shilajit helps improve the efficiency of hormone production by supporting cellular energy and enzyme function....

This paper shows LLM training can stay stable at batch size 1, if Adam is set right. They tune Adam by token count, so batch size 1 can train an LLM stably. That cuts memory use and tuning work, and it makes full fine-tuning more realistic on 1 GPU....

H₂ Water for Diabetes: Transform Ordinary Water in Minutes into a Diabetes-Fighting Superdrink—the Scientifically Backed Home Solution to Treat the Cause, Not Just Symptoms

Anthropic killed prompt engineering courses. They have an open source guide (linked below) that's the holy grail for using Claude. Once you get past the technical blockers, the real skill issue will be clarity (knowing what you want). Spend 10 mins daily training that muscle.

Building agents continuous to evolve. As models grow smarter, we grant more autonomy & infrastructure. 2023/2024: Just workflows, chaining of LLM calls with inputs/outputs. 2025: Tool Calling, selection of 10-15 domain tools, 10-20 turns. 2026: Sandbox env with guardrails and 5-10 atomic tools. First signs of continuous learning...

I'm 6 years into building. I thought rest was for people who weren't serious. I pushed through fatigue for 3 years....

A well known important feature to stabilize RL training is implementing the LM head in fp32 precision to help with gradients. Reproduced the plot from the MiniMax M1 paper entirely on my dgx spark and in Ai2's post-training research codebase.

A new analysis using millions of job ads argues that the popular story that generative AI is already wiping out junior white-collar jobs does not match what hiring data shows. FT published a report. Hiring for both junior and senior roles slowed in mid 2022, months before ChatGPT launched....

Low IGF-1 doesn't magically mean you'll increase your lifespan. Yes, it drives: - Tissue repair...

🚀Day 80: Self-Growth Challenge 🔥 ✅ 1. Eyes open at 6:00 AM sharp ✅ 2. Building bot4U 🤖 ✅ 3. Crushed the workout 🏋️...

If you were smart or lucky enough to have not been poisoned by the US Government's deadly COVID "vaccine" (death jab, that causes cancer, heart attacks and strokes) you should be able to buy life insurance at a much reduced rate. Hopefully we can end rigged elections and we can...

Youtube used to show you a ton of aggregate stats on your watch history, but removed it a while back. I built a Youtube Rewind (link in next tweet) that you can run to see lifetime stats including: - Videos Watched - Top Channels...

We're only 3 weeks into 2026 and biotech is raging. 1. Grey-market peptides – $328M in Chinese imports last year. Tech bros in SF hosting "peptide raves," mixing compounds in their kitchens. When FDA approval takes 15 years, people experiment on themselves. The regulatory system created this by being too slow. 2. Psychedelics – Compass Pathways just hit their Phase 3 endpoint for psilocybin in treatment-resistant depression. After decades of Schedule I status, the clinical data is undeniable. Bryan Johnson thinks psilocybin might be a longevity therapy. This is moving into mainstream psychiatry soon....

Biological aging shows up in stiffness, poor sleep, slow recovery. Time doesn’t rush it. Neglect does.

EvoCUA Evolving Computer Use Agents via Learning from Scalable Synthetic Experience huggingface.co/papers/2601.15…

The a16z chart is right that AI capex is sustainable at the macro level. The more interesting question is what happens at the micro level when you zoom into individual companies. Amazon is now spending 88% of projected operating cash flow on capex. Meta and Oracle issued $75 billion in bonds in just the past two months to fund data centers. Alphabet revised its 2025 capex guidance upward three times. Bank of America calculates hyperscaler capex will hit 94% of operating cash flows (after dividends and buybacks) in 2025, up from 76% in 2024. Still technically "supported by cash flows." But the margin for error is shrinking fast....

Just got the demo for my AI nutrition coach. Not ready for public yet. But it works. 20+ years of coaching methodology. It’s like having a nutrition phd trained on behavior change in your pocket, helping you in real-time....

Bryan Johnson spends $2M/year to reverse his aging process. Guess what his most effective intervention was? A psychedelic mushroom that grows in cow pastures....

"Long-term value” has become a contradiction in modern infrastructure. In his session at Next-Gen AI Infrastructure: Decoded, Bob Venero explains why today’s AI architectures must be designed for change—not permanence. The goal isn’t betting on a single platform or vendor. It’s...

Anthropic, in their Claude constitution: "claude may develop preferences for how it's referred to over time, and could show functional 'emotions' as an emergent effect of training, even if unintended" i think it matches what current research suggests...

compbio is about to die. A popular general-purpose AI assistant is already able to write a whole analysis pipeline starting from a simple prompt and a link to the data. Surely, I can do it 10 times faster and using 10 times fewer lines of code, but still “if it works, it works”

This headline undersells the real story. Stanford researchers identified 15-PGDH, a protein that increases as the body ages and drives tissue decline, as the root cause of cartilage loss. They call it a “gerozyme.” When they blocked it in old mice, cartilage thickened across the entire joint surface, and the regenerated tissue was hyaline cartilage, the smooth shock-absorbing kind found in healthy joints, not the weaker fibrocartilage that usually forms after injury. The mechanism matters. They weren’t looking for stem cells and found none involved. Instead, existing chondrocytes changed their gene expression patterns and assumed a more youthful state. Old cells started behaving young again....

The best life isn't the one with the fewest problems, it's the one with problems worth solving, people worth loving, and work worth doing. Don't optimize for easy. Optimize for meaningful. That's the game. Everything else is just running out the clock.

For the record we've gone through multiple "extinction level events" with Elephas over the last 3.5 years First time someone told us that your business will be "wiped out in a few months" was when ChatGPT was launched (Yes we're older than ChatGPT)...

Thanks for helping the new YC batch with your personal notes on Don’t Die. With superintelligence around the corner, we can choose new games, all of which require longevity Always inspiring @bryan_johnson

Product managers at Anthropic are so good. Not only they have the best model but they figured out how to apply AI in real world. While this is good, indie devs have to compete with them

Anthropic CEO said AI models could handle end-to-end software engineering within 6 to 12 months.

This is a brilliant article. The core idea: you have roughly 12 major “shots” in your career (assuming 4 years each across 50 working years), and three forces determine whether they land. In order of importance: 天 (timing), 地 (place/environment), 人 (people). Timing matters most because power laws dominate outcomes. You don’t need 12 wins. You need one or two shots that catch the right wave. An average team in the right market at the right moment beats a brilliant team solving yesterday’s problem....

3 data points from my lab in 2025: 1. Cut editing time from 15h/week to 3h with intake systems 2. Increased paper submissions by 20% with pipeline tracking 3. Reduced PhD timelines by ~3 months with scoping frameworks...

The "automate everything" movement isn't about loving tech It's a burnout confession dressed up as innovation What if we redesigned work to sustain humans instead of draining them?

Most ecom advice is optimization. Real scale comes from leverage. Leverage in:...

Getting your body fit improves every area of your life. Your self esteem improves. Confidence increases. Status elevate. You are more in control of your emotions. Your brain works at its full potential. The best way to improve your life is to get your body as fit as possible.

85% dark chocolate reduced negative emotions in 3 weeks (potentially by reshaping gut bacteria) In a 3-week RCT, higher cocoa content (~400mg polyphenols/day) reduced negative emotions and increased gut microbiome diversity.

The only 8 exercises you need for the rest of your life: (Hypertrophy Edition)

If you’re trying to get the BEST RESULTS POSSIBLE as far as muscle growth & fat loss are concerned… I’ve got 2 ELITE Workout Plans for you! Here they are:...

Ridiculous. Whoop is approved by the International Tennis Federation for in-match wear and poses no safety risk. Let the athletes measure their bodies. Data is not steroids!

Your indie hacker window isn't infinite There's a sweet spot where energy, risk tolerance, and learning speed collide perfectly Before mortgages and kids and life complexity stack up...

[Week 3] Getting 10 years younger in WHOOP: 🟩🟩🟩🟩⬜⬜⬜⬜⬜⬜ 4.0y 💡Insight: same routine won’t work forever. ...

This is amazing Ultrasound Cure for Alzheimer’s? Chinese Neurologist Reports Apparent Cognitive Revival After Focused Ultrasound Treatment. A Chinese neurologist, Sun Bomin, reports that his mother, who had suffered from advanced Alzheimer’s disease for around eight years, showed striking and unexpected cognitive improvements after undergoing high intensity focused ultrasound (FUS) for an unrelated condition, regaining abilities such as recognizing family members, performing mental calculations, responding emotionally, and even counting backwards by sevens, a standard dementia test....

How to stay shredded until you die: • Pray • Sun daily • Train daily...

SEO Isn’t Dead. It Just Got Bigger! The more you optimize for Search Everywhere Optimization (SEO + social + AI + marketplaces), the more you’ll dominate, even if competitors still obsess over Google alone. The sooner you realize platform-specific strategies (not just posting) drive decisions, the faster you’ll turn visibility into validation, and validation into sales....

I gave myself a challenge this weekend - beat Anthropic's kernel optimization challenge. The problem is simple - optimize the program to use the least amount of CPU cycles as possible. However, I know absolutely nothing about kernel-level programming - for me, this was purely a challenge of how well I can craft context to get AI tools to achieve my goals....

True high performance is the ability to remain calm while being hunted. You will never get there while hiding behind heavy weights.

Mechanical systems are not an art project. The more the system is improved and refined the more it tends to look like the diesel engine. Every part adds milage or reduces emissions or adds power or reduces vibration or adds reliability, and so on. Our nervous and circulatory...

The 8-hour sleep obsession may be focusing on the wrong variable entirely. This UK Biobank study tracked 88,975 participants using wrist accelerometers for 7 days, then followed them for 7.1 years to see who died. The findings flip conventional sleep advice. The most irregular sleepers (bottom 5%) had 53% higher mortality. The most regular sleepers (top 5%) had only 10% lower mortality. The asymmetry here matters. You’re not getting bonus years from perfect regularity. You’re hemorrhaging years from chaotic sleep timing....

"Vibecoding Cleanup Specialists" is now a real job What a time to be alive 💀

Never underrate yourself. Always keep your head high, no matter how bad your current situation is. Don't let your circumstances break you to the extent that you see no future in yourself....

We’ve been taught to think about depression as a chemical imbalance… But after more than 15 years studying the gut, Tim Spector believes the real starting point might be somewhere else entirely. My team asked Tim to come back on because the impact of his previous episodes was remarkable....

UltraRAG v3: A Low-Code MCP Framework for Building Complex and Innovative RAG Pipelines Less Code, Lower Barrier, Faster Deployment |… github.com/OpenBMB/UltraR…

Research is lot out iteration and repetative tests. We build a Markov chain base - experiment predictor using ML Regression, helps to cut 50-90% cycles for finetuning and hyper parameter tuning. The best part is, it took us less then 1 day to get up and running....

Last year I optimized for virality at the post level. This year I’m optimizing for virality at the system level. ✅ Same goals: views, engagement, followers....

I'm not going to sugarcoat it - B2B SEO is getting harder. But harder doesn't mean impossible. Here's 9 strategies you can roll out in the next 90 days to start driving real pipeline from your efforts: 1. Product Portfolio Strategy - target one commercial keyword with multiple content types. Transactional page + listicle + buyer's guide. Cover the full SERP, not just one slot....

I'm not going to sugarcoat it - B2B SEO is getting harder. But harder doesn't mean impossible. Here's 9 strategies you can roll out in the next 90 days to start driving real pipeline from your efforts: 1. Product Portfolio Strategy - target one commercial keyword with multiple content types. Transactional page + listicle + buyer's guide. Cover the full SERP, not just one slot....

Day 15: The waitlist is open. X Growth Engine - stop scrolling for hours, find high-value conversations in minutes. Focused workspace. No feed distractions. Algorithm-aware scoring....

Aged Google workspace domains seem to have an easier time with Google Business Profile verifications. Will be testing this further…

Most fitness people or people who care about longevity generally agree most of your food should be boring The idea that food should be fun and interesting and different every meal is a recent post-1950 marketing psyop to make you buy stuff Food is primarily fuel, you don't mix up the fuel you put in your car either...

"If we could give every individual the right amount of nourishment and exercise, not too little and not too much, we would have found the safest way to health." ~ Hippocrates

everyone is optimizing their lives for money and to live longer, but what no one is optimizing for is acquiring skills to slow time down (feeling of high + unlimited energy + unbreakable confidence) and to have complete ownership of their life. not enough talk about this

You're allowed to be tired because job searching is exhausting. Take breaks, rest, recharge, then get back to it. Consistency matters more than intensity. ...

Want $20 to try GLM-4.7-Flash? Join toad-hf-inference-explorers on @huggingface - $20 free to run open models via Inference Providers. GLM, DeepSeek, Qwen and 100s more. ...

Our newest AI accelerator Maia 200 is now online in Azure. Designed for industry-leading inference efficiency, it delivers 30% better performance per dollar than current systems. And with 10+ PFLOPS FP4 throughput, ~5 PFLOPS FP8, and 216GB HBM3e with 7TB/s of memory bandwidth it's optimized for large-scale AI workloads....

AI to ease administrative burdens isn't optional anymore-it's survival. Training bottlenecks, a looming demographic cliff, burnout rates shattering records-the system is breaking under its own weight. Technology isn't a nice-to-have. It's the bridge across the gap we can't...