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It wont be long now before we have the technology to compute the complexity of biology and replicate it mechanically.
When they combine this👇🏻 with photonics and synthetic biology, "humans" will be obsolete.
That's their goal btw. To use technology to turn themselves into "Gods". ...
"Study something old but not visibly useful (classics), something modern and useful (accounting, coding), never something new and not visibly useful." - Nassim Nicholas Taleb amazon.com/gp/product/198…
HOLY SHIT.. for the first time in history.. age reversal is going into human trials..
David Sinclair's team at Harvard figured out how to reprogram old cells back to a younger state using something called Yamanaka factors.. four proteins discovered in 2006 that can reset adult cells to an embryonic-like state..
in mice they reversed aging in damaged muscle and brain tissue.. extended lifespan in mice with accelerated aging.. and restored memory in elderly mice.. in lab tests cells appeared 75% younger after 8 weeks.....
Cool new paper:
Cellular aging biomarkers in primates - increasingly supportive of aging being a software problem
But what kind of software? And can an update be reinstalled? 🧵
𓂀 Me today…
going up against my corporate overlords & standing ten toes down in my expertise:
“I am not fully convinced we need to move from standard marketing optimization into a more neuroscience-based or quasi-biometric persuasion model when we still have such a vast upside in the data, testing opportunities, & tools already within our own ecosystem. My hesitation is less about whether Neurons AI is credible…
& more about fit, timing, & consumer threshold. There is a noticeable difference in today’s digital climate between optimizing against clicks, opens, conversions, & purchase behavior VS. optimizing against attention signatures, emotional-response modeling, or eye-tracking / neural prediction.
...
Words that I think will be obsolete by 2028
- “agent” = every product is agentic
- “browser” = humans access the internet via agents, not browsing
- “onboarding” = every product auto-ingests your context ...
AI is a longevity therapy for corporations.
As companies age:
> arterial calcification - information flow narrows
> joints stiffen - decisions slow ...
Artificial intelligence-driven chatbots are giving users problematic medical advice about half the time, a new study found, highlighting the health risks of a technology that's becoming an integral part of daily life. ebx.sh/h2sdwh
Japanese quail bred to lay larger eggs showed faster biological aging and about 20% shorter lifespans, underscoring a genetic trade-off between reproductive investment and longevity. doi.org/hbxbfkphys.org/news/2026-04-b…
We've been conditioned to believe that health means silence…
As long as the body doesn't bother us, we assume everything is fine…
The moment it speaks up, we call it malfunction.
AI companies keep promising that advanced AI will magically cure cancer & solve aging.
But this analysis suggests the petabytes of biomedical training data that would be required do not exist, & would take centuries of time, & trillions of dollars, to collect.
I CTO'd $DOOM and this deserves to go just as high / higher.
Health and bio related tech is always cool to see when it crosses over into crypto with token launches, especially since the tech can have a far-reaching impact.
Hoping this can fly to support Marc's work
Calling innovators and startups in life sciences & related disciplines!
Join us to turn your ideas into reality with access to advanced genomics & proteomics core, Experimental Animal Facility, high-end instrumentation, expert mentorship & a strong startup community. (1/2)
Tennis and even better, padel, truly cause longevity.
It’s not just because the people who play tennis have better access to medical care and eat better.
It’s the cognitive, aerobic, and above all social exercise that matters....
Sobering paper on aging
Argues that basically every intervention known to extend lifespan only does so by preventing obesity.
In other words, being lean and fit is not just 90% of slowing aging, but 100%....
Sometimes you guys ask me what I’m looking for in a man.
I like older men with dom energy. Older isn’t required but dom energy def is.
He needs to know how to take control. Fitness and health consciousness are important too. ...
“Every attempt to neutralize leads only to a new domain of struggle… The process of neutralization… ends with technology.”
Carl Schmitt, The Age of Neutralizations and Depoliticizations
India’s life expectancy has doubled since 1950. But 65% of deaths are still from diseases caught too late.
Cent, the new startup from Practo’s founder, thinks it has an answer: full-body AI scans that find risks before they become diagnoses. (🧵⤵️)
The fitness industry sells you optimization.
"What's the optimal rep range?" "What's the optimal exercise?" "What's the optimal split?"
Brother, you can't get past 6 weeks of consistency. ...
All cancers will be curable by 2030s
Immunotherapy is changing the game. Treatments that activate your immune system (like checkpoint inhibitors and CAR-T) are already producing long term remissions in cancers that used to be near certain death sentences.
Early detection is getting radically better. Liquid biopsies (blood tests that detect cancer early) could catch tumors before they even form symptoms, which massively increases cure rates....
someone healthy died young so now you're not going to exercise
someone died in a car crash so now you're not going to wear a seatbelt
the logic is identical....
The FDA's move toward regulatory clarity on peptides is overdue and welcome. At Superpower, we believe every American deserves a responsible pathway to the innovations extending healthy life.
Read our joint statement from Max Marchione, Founder & CEO, and Dr. Anant Vinjamoori, Chi...
We're gonna improve / save so many lives now that we can cheaply sequence someone's entire genome (and better understand that data with AI). I did it myself + I'm hopeful we'll see such progress in next few yrs that medicine today will look antiquated.
x.com/i/status/20451…
The "healthy" label is doing a lot of heavy lifting.
Fruit juice, granola, flavored yogurt, whole wheat bread, protein bars, these aren't junk food. That's exactly what makes them tricky. They carry a health halo that can quietly work against your metabolic health over time.
Healthspan optimization isn't about eating perfectly. It's about understanding why certain foods work for your biology and making smarter swaps where it counts....
The Convergence Is Already Here. Are You Ready? 🚀
Something unprecedented is happening.
AI, humanoid robotics, longevity science, and other exponential tech are no longer developing in parallel. They are converging, multiplying each other's impact in real time. And the pace of that convergence is accelerating faster than most leaders realize....
I wish there were a way to better incentivize the tech world to use AI to drive scientific breakthroughs that cure disease.
I wish that’s what the brilliant people building AI were mostly focused on and talking about.
The worst thing about life is that it can all be taken away tomorrow.
When last did you go for a Medical checkup ?
Dear Entrepreneur & Tech Bro, your health is a treasure that you must guard 💂♂️, so you can live to enjoy your labour today.
Take care of yourself, awesome person ❤️
Be Danny Cortenraede.
> VC investor who applies due diligence to his own biology
> Tracks energy like a portfolio metric
> Treats sleep consistency like a non-negotiable fund rule
> Asks 'how can I be helpful if my health fails first?'...
Congratulations to almost everyone under ~70-80, aging as we know it is on borrowed time. AI won’t just slow it down, it will help us figure out how to reverse it.
“I was a doomer, and I work in tech. I signed the anti-AI deceleration. Bought into all the catastrophic authors. But you and your 5000 days series changed me…I don’t know why you are not quoted all over the place”
Thank you! Deep gratitude.
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Complementing this, enterprises are often evolving from “let a thousand flowers bloom” approach to adoption to targeted automation efforts applied to specific areas of work and workflow.\n\n* Change management still will remain one of the biggest topics for enterprises. Most workflows aren’t setup to just drop agents directly in, and enterprises will need a ton of help to drive these efforts (both internally and from partners). One company has a head of AI in every business unit that roles up to a central team, just to keep all the functions coordinated.\n\n* Tokenmaxxing! Most companies operate with very strict OpEx budgets get locked in for the year ahead, so they’re going through very real trade-off discussions right now on how to budget for tokens. One company recently had an idea for a “shark tank” style way of pitching for compute budget. 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Enterprises need to be able to ensure all of their software works across any set of agents they choose. They will kick out vendors that don’t make this technically or economically easy.\n\n* Clear sense that it can be hard to standardize on anything right now given how fast things are moving. Blessing and a curse of the innovation curve right now - no one wants to get stuck in a paradigm that locks them into the wrong architecture. One other result of this is that companies realize they’re in a multi-agent world, which means that interoperability becomes paramount across systems.\n\n* Unanimous sense that everyone is working more than ever before. AI is not causing anyone to do less work right now, and similar to Silicon Valley people feel their teams are the busiest they’ve ever been.\n\nOne final meta observation not called out explicitly. It seems that despite Silicon Valley’s sense that AI has made hard things easy, the most powerful ways to use agents is more “technical” than prior eras of software. Skills, MCP, CLIs, etc. may be simple concepts for tech, but in the real world these are all esoteric concepts that will require technical people to help bring to life in the enterprise. \n\nThis both means diffusion will take real work and time, but also everyone’s estimation of engineering jobs is totally off. 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One company has a head of AI in every business unit that roles up to a central team, just to keep all the functions coordinated.\n\n* Tokenmaxxing! Most companies operate with very strict OpEx budgets get locked in for the year ahead, so they’re going through very real trade-off discussions right now on how to budget for tokens. One company recently had an idea for a “shark tank” style way of pitching for compute budget. Others are trying to figure out how to ration compute to the best use-cases internally through some hierarchy of needs (my words not theirs).\n\n* Fixing fragmented and legacy systems remain a huge priority right now. Most enterprises are dealing with decades of either on-prem systems or systems they moved to the cloud but that still haven’t been modernized in any meaningful way. 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